Bile acids are produced from cholesterol in the liver. These molecules are released from storage in the gall bladder into the intestine where they are reabsorbed and influence blood lipid levels. Lodalis is a bile acid sequestrant which is prescribed, in addition to appropriate diet and exercise, to treat elevated cholesterol levels, particularly in the reduction of low-density lipoprotein cholesterol (LDL-C). This medication functions by binding to bile acids in the intestine and inhibiting reabsorption, thereby decreasing cholesterol levels.
Lodalis may be used to lower cholesterol in individuals who are inadequately controlled on statin monotherapy, or those who are intolerant to statins. Additionally, Lodalis may be used along with metformin, sulfonylureas, or insulin therapy to improve blood glucose levels in individuals with type 2 diabetes. The mechanism by which Lodalis lowers blood sugar levels is currently unknown.
Before Taking Lodalis
Before taking Lodalis, be sure to talk to your doctor about any previous or current medical conditions you have, particularly stomach or intestinal problems, or elevated triglycerides. Tell your doctor if you are currently taking any other medications, including prescription and non-prescription medications, vitamins, and herbal supplements, as some medications may interact with Lodalis.
Dosage and forms
Lodalis should not be taken by individuals who:
Lodalis is formulated into 625mg tablets. The maximum recommended daily dose of this medication is generally 3.75g, which can be taken as 6 tablets once daily or 3 tablets twice daily.
Lodalis should be taken with food and liquids.
Do not chew or crush this medication upon administration; swallow tablets whole
Be sure to take this medication exactly as prescribed by your doctor.
Talk to your doctor if you experience any side effects while taking Apidra.
When Lodalis should not be used
Have a history of bowel obstruction or those who are at risk of bowel obstruction
Have a history of hypertriglyceridemia-induced pancreatitis
Have fat-soluble vitamin deficiencies
Are pregnant or breastfeeding
Are allergic to colesevelam hydrochloride
Have significantly elevated triglycerides
Warnings and Precautions
Lodalis can increase triglycerides, particularly when used with insulin or sulfonylureas. Marked hypertriglyceridemia can cause acute pancreatitis. Individuals who are prescribed Lodalis should have their lipid levels tested on a regular basis.
Bile acid sequestrants may decrease absorption of fat-soluble vitamins. Lodalis should be used with caution in patients susceptible to fat-soluble vitamin deficiencies
Because of its constipating effects, Lodalis is not recommended in patients who are at risk of bowel obstruction (e.g., patients with gastroparesis, other gastrointestinal motility disorders or a history of major gastrointestinal surgery)
Lodalis reduces gastrointestinal absorption of some drugs. Administer drugs with a known interaction with colesevelam at least 4 hours prior to Lodalis.
Side Effects
The most common side effects reported by individuals taking Lodalis include:
Constipation
Dyspepsia (indigestion)
Nausea
These symptoms have generally been found to subside with continued Lodalis therapy, although you should talk to your healthcare provider if these or any other side effects of Lodalis become troublesome.
